Risk factors associated with the development of interstitial lung abnormalities
نویسندگان
چکیده
Background Around 8–10% of individuals over 50 years age present interstitial lung abnormalities (ILAs), but their risk factors are uncertain. Methods From 817 recruited in our ageing programme at the Mexican National Institute Respiratory Diseases, 80 (9.7%) showed ILAs and were compared with 564 same cohort normal high-resolution computed tomography to evaluate demographic functional differences, randomly selected from for biomarkers. We evaluated MUC5B variant rs35705950, telomere length, serum levels matrix metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, interleukin (IL)-6, surfactant protein (SP)-D, α-Klotho resistin. Results Individuals usually males (p<0.005), older than controls (p<0.0001), smokers (p=0.01), a greater frequency rs35705950 (OR 3.5, 95% CI 1.3–9.4; p=0.01), reduced diffusing capacity carbon monoxide oxygen saturation. Resistin, IL-6, SP-D, MMP-1, MMP-7 MMP-13 significantly increased ILAs. Resistin (12±5 versus 9±4 ng·mL −1 ; p=0.0005) (357±143 298±116 pg·mL p=0.004) most On follow-up (24±18 months), 18 progression which was associated gastro-oesophageal reflux disease 4.1, 1.2–12.9; p=0.02) females diabetes mellitus 5.3, 1.0–27.4; p=0.01). Conclusions 10% respiratory asymptomatic enrolled show Increased concentrations pro-inflammatory molecules MMPs
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ژورنال
عنوان ژورنال: The European respiratory journal
سال: 2021
ISSN: ['0903-1936', '1399-3003']
DOI: https://doi.org/10.1183/13993003.03005-2020